With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.
Under an argon atmosphere a carbene complex of formula 5.II, wherein L represents a NHC ligand of formula 6a.II (153 mg, 0.18 mmol),and anhydrous CuCl (18 mg, 0.18 mmol) were placed in a Schlenck tube. Then dry, deoxygenated CH2C12 (10 ml) was added followed by a solution of compound 2.1 (38 mg, 0.18 mmol) in CH2C12 (4 ml). The resulting suspension was stirred at 30C for 1 h, thereafter it was concentrated in vacuum, and purified by silica-gel column chromatography (cyclohexane / EtOAc 5:2). After removal of solvent and washing with small amount of dry n-pentane complex 1.II, wherein Mes has the meaning of a mesityl group, was obtained as green, microcrystalline solid (100 mg, 83% of yield). Rf = 0.30 (hexane/EtOAc8:2);XH-NMR (500 MHz, CD2Cl2): delta[ppm]= 16.42 (s, 1H), 8.46 (dd, 1H, J = 9.1, 2.5 Hz), 7.80 (d, 1H, J = 2.5 Hz), 7.10 (s, 4H), 6:94 (d, 1H, J = 9.1 Hz), 5.01 (sept, 1H, J = 6.1 Hz), 4.22 (s, 4H), 2.47 (2s, 18H), 1.30 (d, 6H, J = 6.1 Hz); 13C-NMR (125 MHz, CD2Cl2): delta;[ppm]= 289.1, 208.2,156.8, 150.3, 145.0, 143.5, 139.6,139.3,129.8, 124.5,117.2,113.3, 78.2, 52.0, 21.3, 21.2,19.4; IR (KBr): nu [cm-1] = 2924, 2850,1606,1521,1480,1262, 1093, 918,745; MS (ESI): m/z 636 [M-CI]+; HRMS(EI): m/z calculated for C31H37N3O3Ru: [M+.] 671.1255, found 671.1229; Elemental analysis, calculated: (%) for C31H37N3O3Ru (671.63): C 55.44, H 5.55, N 6.26; found: C 55.35; H 5.70, N 6.09., 246047-72-3
The synthetic route of 246047-72-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI