Downstream synthetic route of 172222-30-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.172222-30-9,Benzylidenebis(tricyclohexylphosphine)dichlororuthenium,as a common compound, the synthetic route is as follows.,172222-30-9

In a glove box, NHC ligand precursor 23 (162 mg, .34 mmol), ruthenium precursor 5 (150 mg, .27 mmol) and KOt-Bu(Fe) (74 mg, .34 mmol) were combined in C6D6 and stirred at RT for 2.5 hours. The flask was sealed, removed from the glove box and the reaction was concentrated and purified by flash column chromatography (2.5percent – > 5percent Et2psi/Pent) to yield a brown oil. The brown oil was lyophilized from benzene to give 25 as a brown solid (66 mg, 25percent). 1H NMR (300 MHz3 CDCl3) delta 20.07 (d, J = 10.5 Hz, IH)3 8.03 (br, 2H), 7.60 (t, 1.8 Hz, IH), 6.86-6.81 (ra, 2H), 6.51 – 6.47 (m, IH), 1.81 – 1.07 (m).

172222-30-9 Benzylidenebis(tricyclohexylphosphine)dichlororuthenium 60145889, aruthenium-catalysts compound, is more and more widely used in various.

Reference£º
Patent; MATERIA, INC.; CALIFORNIA INSTITUTE OF TECHNOLOGY; WO2007/75427; (2007); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI